ICRS Presidents Issue
ICRS past presidents share their insights and research that impact the global community.
Current state of off the shelf scaffolds and implants for meniscal replacementPartial meniscectomy has been a mainstay of treatment for mechanical symptoms of meniscal tear for decades. Yet, clear changes in load distribution have been reported after loss of meniscal integrity and degenerative changes have been seen after these procedures over time. While meniscal repair is preferred whenever possible, these repairs are not always possible or successful. In recent years options have been developed to try to mitigate these post meniscectomy symptoms and sequelae, including off-the-shelf scaffolds and implants for meniscal replacement.
The biology of mesenchymal stem/stromal cells in the treatment of osteoarthritisOsteoarthritis affects the whole joint and is usually treated using pain relief for many years followed by arthroplasty. Mesenchymal stem/stromal cells have the potential to form cartilage and bone and have been investigated for their capacity to repair these tissues, but until recently there has been no strong rationale for their use in the treatment of age-related, idiopathic osteoarthritis.
Anterior cruciate ligament graft healing by peptide-based vascular endothelial growth factor and bone morphogenetic protein recruitmentThe frequency of adverse outcomes after revision ACLR emphasizes the importance of the primary reconstruction regarding intra-articular graft healing and tunnel osteointegration.
A review of bone marrow lesions in the arthritic knee and description of a technique for treatmentSubchondral bone pathology includes a wide range of pathologies, such as osteoarthritis, spontaneous insufficiency fractures, osteonecrosis, transient bone marrow lesions syndromes, and trauma. They show typical magnetic resonance imaging (MRI) findings termed bone marrow lesions (BMLs). However, the etiology and evolution of BMLs in multiple conditions remains unclear. There is still no gold standard treatment protocol in treating BMLs in the knee, and a variety of treatment modalities have been tested in the hope that they might reduce pain and stop disease progression.
Bone Marrow Concentrate Mesenchymal Stromal Cells Do not Correlate With Nucleated Cell Count or Colony Forming UnitsBone marrow aspirate concentrate (BMC) is a point-of-care biologic for cartilage repair and treatment of osteoarthritis. BMC contains mesenchymal stromal cells (MSCs) which are technically difficult to measure, and therefore the extent to which they influence joint restoration is unknown. Nucleated cell count (NCC) and colony forming units (CFUs) have been proposed as surrogate markers to quantify MSCs in BMC.
Periosteum-covered ACI (ACI-P) versus collagen membrane ACI (ACI-C): A single-surgeon, large cohort analysis of clinical outcomes and graft survivorshipAutologous chondrocyte implantation (ACI) has undergone several technical modifications.